News

eLife23h
The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the Drosophila gut
The Drosophila microbiome regulates the cycling of gut metabolites in a circadian clock and diet-dependent manner.
eLife1d
Glycosylated IgG antibodies accelerated the recovery of haemorrhagic fever with renal syndrome patients
The authors investigated the potential role of IgG N-glycosylation in Haemorrhagic Fever with Renal Syndrome (HFRS), which may offer significant insights for understanding molecular mechanisms and for ...
eLife3d
REPOP: bacterial population quantification from plate counts
This important study introduces a Bayesian method to determine bacterial counts that accounts for the experimental noise inherent to dilution and plating methods, and distinguishes it from biological ...
eLife3d
Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p
This important study presents a new method for longitudinally tracking cells in two-photon imaging data that addresses the specific challenges of imaging neurons in the developing cortex. It provides ...
eLife3d
Long-term live imaging, cell identification and cell tracking in regenerating crustacean legs
This study presents a valuable technical advance in the long-term live imaging of limb regeneration at cellular resolution in Parhyale hawaiensis. The authors develop and carefully validate a method ...
eLife10d
Current insights into insect immune memory
Insects possess a remarkable ability to develop innate immune memory, and the mechanisms underlying this process are becoming a central topic in innate immunity research.
eLife4d
Reorganization of spinal neural connectivity following recovery after thoracic spinal cord injury: insights from computational modelling
Rats exhibit significant recovery of locomotor function following incomplete spinal cord injuries, albeit with altered gait expression and reduced speed and stepping frequency. These changes likely ...
eLife7d
Cestode larvae excite host neuronal circuits via glutamatergic signalling
Parasitic tapeworm larvae release glutamate and other excitatory molecules that can directly excite brain neurons.
eLife8d
Assemblies, synapse clustering, and network topology interact with plasticity to explain structure-function relationships of the cortical connectome
This useful study presents a biologically realistic, large-scale cortical model of the rat's non-barrel somatosensory cortex, investigating synaptic plasticity of excitatory connections under varying ...
eLife11d
Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues
Large-scale microscopy combined with tissue clearing and expansion enables nanoscale imaging of centimeter scale specimens.
eLife3d
Quantitative intra-Golgi transport and organization data suggest the stable compartment nature of the Golgi
Quantitative measurements of intra-Golgi transport kinetics of diverse secretory cargos challenge the classic cisternal progression model and support the stable compartment model of the Golgi.
eLife11d
Methylation: Modifying gene expression through passive forces
The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.