In the current anti-immigrant political environment in the United States, what will happen when immigrants who work in the health care system are forced to leave?

This editorial explains the genetic basis of Pompe’s disease and other lysosomal storage disorders, as well as the foundations of enzyme-replacement therapy.

The Supreme Court recently agreed to hear a case about adolescent e-cigarette use and the FDA’s role in addressing it. A ruling against the FDA could have implications for its authority and for ...

Among women with a history of early breast cancer treated with endocrine therapy (tamoxifen or aromatase inhibitors), vasomotor symptoms are common, occurring in up to 90% of this population, and o ...

This editorial explains the science behind a study of chimeric antigen receptor–expressing T cells to treat a series of 27 patients with neuroblastoma.

A 60-year-old man with hypertension and bipolar disorder was incidentally found to have small cysts on his kidneys during MRI of the abdomen.

A previously healthy 3-year-old boy presented with vomiting and fevers. Purpura developed on his body that evolved with the patient’s response to treatment.

A 32-year-old man presented with recurrent dysphagia caused by food impaction. Endoscopy revealed trachealization of the esophagus, and a diagnosis of eosinophilic esophagitis was made.

What does a solutions-oriented conversation about U.S. health care look like at the state level, how do we get there, and what does a shift toward state action mean for the future of reform? State ...

A 4-year-old boy had a 2-day history of right hip pain and limping. A radiograph showed a focal area of collapse in the right femoral head.

Navigating cases of potential self-neglect is complicated for older adults and for the family members, clinicians, and social and legal services professionals involved in ensuring their well-being.

Explore this issue of The New England Journal of Medicine (Vol. 377 No. 14).